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There will be at least three changes between the sides when Leeds Rhinos and Wigan Warriors meet for the second time in nine days on Saturday.

Rhinos go into the Betfred Challenge Cup sixth round tie at Headingley buoyed by last week’s 40-18 away Super League win over Wigan, but that cost them two first-choice forwards.

Zane Tetevano was sent-off in the first half and begins a two-match ban this weekend, while fellow starting second-rower James Bentley failed a head injury assessment and is ruled out through the concussion protocol.

But Rhinos could welcome back scrum-half Aidan Sezer who has been included in their initial squad for the first time since suffering a quad muscle injury in a defeat at Leigh Leopards on April 21.

Aidan Sezer is back in Rhinos' squad. Picture by John Clifton/SWpix.com.

Former Wigan second-rower James McDonnell is available following the arm injury which kept him out of last week’s game.

Corey Johnson, Derrell Olpherts, Sam Walters and Luis Roberts, who weren’t selected for the league match, retain their place in the initial 21.

Leeds Rhinos v Wigan Warriors injury news and 21-man squads as 3 ruled out and trio return